EFFECTS OF MELATONIN ON [H-3] THYMIDINE INCORPORATION INTO DNA OF RAT-THYROID LOBES INVITRO

被引：6
|
作者：
WAJS, E
LEWINSKI, A
机构：
[1] Laboratory of Thyrology, Institute of Endocrinology, The University School of Medicine at Łódź
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 181卷 / 03期
关键词：
D O I：
10.1016/0006-291X(91)92064-Q
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of 4-h incubation in the presence of melatonin and N-acetylserotonin on the incorporation of [3H]-thymidine into DNA of the rat thyroid lobes were investigated. Additionally, thyroid lobes were incubated in the exposure to melatonin with thyrotropin jointly. Melatonin, when applied in the lowest concentration examined (10-9M), inhibited [3H]-thymidine incorporation, the effect of other concentrations (10-6M - 10-8M) being not significant. N-acetylserotonin (10-6M) did not affect the rate of incorporation of that labelled nucleoside. As expected, thyrotropin enhanced the [3H]-thymidine incorporation into DNA of thyroid lobes. Melatonin (10-7M) suppressed that stimulatory effect of thyrotropin. The participation of melatonin in the regulation of thyroid growth processes is considered. © 1991.
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页码：1187 / 1191
页数：5
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