ANGIOTENSIN-CONVERTING ENZYME-ACTIVITY AS A PROGNOSTIC FACTOR IN ACUTE-RENAL-FAILURE

被引：4
|
作者：
UJIIE, K
TOMITA, K
OWADA, A
MATSUI, N
MARUMO, F
机构：
[1] TOKYO MED & DENT UNIV, DEPT INTERNAL MED 2, BUNKYO KU, TOKYO 113, JAPAN
[2] TSUCHIURA KYODO GEN HOSP, IBARAKI, JAPAN
来源：
NEPHRON | 1991年 / 58卷 / 04期
关键词：
ANGIOTENSIN-CONVERTING ENZYME; ACUTE RENAL FAILURE; RENIN ACTIVITY; KININASE; THYROID FUNCTION;
D O I：
10.1159/000186477
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
We evaluated serum angiotensin-converting enzyme (ACE) activity and thyroid function to determine the importance as prognostic factors in acute renal failure (ARF). Among 37 ARF patients, 24 survived (recovered group) and 13 died (lethal group). Both serum thyroxine (T4) level and ACE activity were lower in ARF as a whole group (n = 37) than normal control group (n = 27, p < 0.01). Both serum T4 level and ACE activity in lethal group (n = 13) were significantly lower than those of the recovered group (n = 24, p < 0.01). Serum ACE activity but not serum T4 level was significantly related to the prognosis of ARF (p < 0.02, Mantel-Haenzel analysis). This suggests that lowered serum T4 levels are not a specific indicator of ARF, but lowered ACE activity is significantly related to the prognosis of the patient in ARF. Serum ACE activity seems to be one several clinically useful prognostic indicators in ARF.
引用
收藏
页码：443 / 449
页数：7
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