Clinical impact and disease evolution of SARS-CoV-2 infection in familial Mediterranean fever

被引：0

作者：

Marinelli, Francesca ^{[1
]}

Caporilli, Chiara ^{[1
]}

Titolo, Annachiara ^{[1
]}

Rigante, Donato ^{[2
,3
]}

Esposito, Susanna ^{[1
]}

机构：

[1] Univ Parma, Pietro Barilla Childrens Hosp, Pediat Clin, Bldg 15,Via Gramsci 14, I-43126 Parma, Italy

[2] Fdn Policlin A Gemelli IRCCS, Dept Life Sci & Global Hlth, Rome, Italy

[3] Univ Cattolica Sacro Cuore, Rome, Italy

来源：

PHARMACOLOGICAL RESEARCH | 2022年 / 182卷

关键词：

SARS-CoV-2; infection; Familial Mediterranean fever; Autoinflammation; Colchicine; Interleukin-1; Innovative biotechnologies; Personalized medicine;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The innate immune system is critically involved in the pathogenesis of familial Mediterranean fever (FMF), characterized by dysregulated inflammasome activity and recurrent inflammatory attacks: this is the most common among monogenic autoinflammatory diseases, which shares some biochemical pathways with the se-vere acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection. In this short review we explore the overlap in the pathophysiology of FMF and SARS-CoV-2 infection, discussing how to understand better the interaction between the two diseases and optimize management. A poorer outcome of SARS-CoV-2 infection seems not to be present in infected FMF patients in terms of hospitalization time, need for oxygen support, need for intensive care, rate of complications and exitus. Long-term surveillance will confirm the relatively low risk of a worse prognosis observed so far in SARS-CoV-2-infected people with FMF. In these patients COVID-19 vaccines are recommended and their safety profile is expected to be similar to the general population.

引用

页数：6

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