HEPATOCYTE PLASMA-MEMBRANE ECTO-ATPASE (PP120/HA4) IS A SUBSTRATE FOR TYROSINE KINASE-ACTIVITY OF THE INSULIN-RECEPTOR

被引:112
作者
MARGOLIS, RN
SCHELL, MJ
TAYLOR, SI
HUBBARD, AL
机构
[1] NIDDK,DIABET BRANCH,BETHESDA,MD
[2] JOHNS HOPKINS UNIV,SCH MED,DEPT CELL BIOL & ANAT,BALTIMORE,MD 21205
[3] HOWARD UNIV,DEPT ONCOL,WASHINGTON,DC 20059
关键词
D O I
10.1016/0006-291X(90)90845-E
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
pp120 HA4, a membrane protein found in hepatocyte plasma membranes and a substrate for the insulin receptor tyrosine kinase, was purified to homogeneity, subjected to partial proteolysis, and peptides were sequenced by Edman degradation. Six amino acid sequences were obtained, and they matched the deduced amino acid sequences of six regions of a hepatocyte membrane protein called ecto-ATPase. © 1990.
引用
收藏
页码:562 / 566
页数:5
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