GLYCOLAMIDE ESTERS OF 6-METHOXY-2-NAPHTHYLACETIC ACID AS POTENTIAL PRO-DRUGS - SYNTHETIC AND SPECTRAL STUDIES

被引：0

作者：

WADHWA, LK ^{[1
]}

SHARMA, PD ^{[1
]}

机构：

[1] PANJAB UNIV,DEPT PHARMACEUT SCI,CHANDIGARH 160014,INDIA

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1995年 / 34卷 / 05期

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D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

6-Methoxy-2-naphthylacetic acid (6-MNA; 1), the active metabolite of newly developed NSAID nabumetone (2) has been modified using prodrug approach. A number of glycolamide ester prodrugs of 6-MNA have been synthesized by masking the free carboxyl group of 6-MNA, mainly responsible for gastric damage, in order to obtain NSAIDs with improved therapeutic index. The structures of these derivatives have been established on the basis of elemental and spectral analyses.

引用

页码：408 / 415

页数：8

共 37 条

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