GLYCOLAMIDE ESTERS OF 6-METHOXY-2-NAPHTHYLACETIC ACID AS POTENTIAL PRO-DRUGS - SYNTHETIC AND SPECTRAL STUDIES

被引：0
|
作者：
WADHWA, LK [1 ]
SHARMA, PD [1 ]
机构：
[1] PANJAB UNIV,DEPT PHARMACEUT SCI,CHANDIGARH 160014,INDIA
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1995年 / 34卷 / 05期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
6-Methoxy-2-naphthylacetic acid (6-MNA; 1), the active metabolite of newly developed NSAID nabumetone (2) has been modified using prodrug approach. A number of glycolamide ester prodrugs of 6-MNA have been synthesized by masking the free carboxyl group of 6-MNA, mainly responsible for gastric damage, in order to obtain NSAIDs with improved therapeutic index. The structures of these derivatives have been established on the basis of elemental and spectral analyses.
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页码：408 / 415
页数：8
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