INTERLEUKIN-13 REGULATES THE PHENOTYPE AND FUNCTION OF HUMAN MONOCYTES

被引：5

作者：

VIALE, G

VERCELLI, D

机构：

[1] IST SCI SAN RAFFAELE,DIBIT,MOLEC IMMUNOREGULAT UNIT,I-20132 MILAN,ITALY

[2] UNIV MILAN,DEPT BIOL & GENET,MILAN,ITALY

[3] HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT PEDIAT,DIV IMMUNOL,BOSTON,MA 02115

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 107卷 / 1-3期

关键词：

CD14; MONOCYTES; INTERLEUKIN-13;

D O I：

10.1159/000236969

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The monocyte glycosylphosphatidylinositol (GPI)-linked protein CD14 serves as the receptor for lipopolysaccharide (LPS), and regulates monocyte-lymphocyte interactions. We investigated whether CD14 expression is regulated by interleukin (IL)-13, a member of the chromosome 5 cytokine family. IL-13 inhibited CD14 expression on human monocytes. CD14 down-regulation resulted in the inhibition of LPS-induced release of tumor necrosis factor alpha, and involved neither shedding nor activation of endogenous GPI-anchor-cleaving enzymes. The CD14/actin RNA ratio was decreased 7-fold in IL-13-treated monocytes. Our results suggest that IL-13 down-regulates CD14 by suppressing CD14 RNA expression. Down-regulation of CD14, the LPS receptor, may play a major role in the anti-inflammatory effects of IL-13.

引用

页码：176 / 178

页数：3