GLYCYLCYCLINES .3. 9-AMINODOXYCYCLINECARBOXAMIDES

被引：25

作者：

BARDEN, TC ^{[1
]}

BUCKWALTER, BL ^{[1
]}

TESTA, RT ^{[1
]}

PETERSEN, PJ ^{[1
]}

LEE, VJ ^{[1
]}

机构：

[1] AMER CYANAMID CO,DIV MED RES,PEARL RIVER,NY 10965

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 20期

关键词：

D O I：

10.1021/jm00046a003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 9-(acylamino)doxycycline derivatives has been prepared. These analogs exhibit good activity against both tetracycline sensitive and tetracycline resistant Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria that are encoded with the efflux and ribosomal resistance gene factors. N,N-Dialkylglycylamido derivatives possessed the highest activity. Replacement of glycine moiety with other amino acids did not further enhance the activity.

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页码：3205 / 3211

页数：7

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