THE STRUCTURE AND EXPRESSION OF THE XENOPUS KROX-20 GENE - CONSERVED AND DIVERGENT PATTERNS OF EXPRESSION IN RHOMBOMERES AND NEURAL CREST

被引:183
作者
BRADLEY, LC
SNAPE, A
BHATT, S
WILKINSON, DG
机构
[1] NATL INST MED RES, EUKARYOT MOLEC GENET LAB, MILL HILL, LONDON NW7 1AA, ENGLAND
[2] NATL INST MED RES, DEV BIOL LAB, LONDON NW7 1AA, ENGLAND
关键词
XENOPUS DEVELOPMENT; KROX-20; RHOMBOMERE; SEGMENTATION; NEURAL CREST;
D O I
10.1016/0925-4773(93)90089-G
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Recent studies in the chick have indicated that rhombomeres (r) are segments that underlie the patterning of hindbrain nerves. These segments may also be important for the specification of branchial arch structures since alternating rhombomeres, r2, r4 and r6, each contribute crest to a specific arch. Krox-20 has been implicated in the segmental patterning of the hindbrain in the mouse by its expression prior to segment formation in alternating domains, which later correspond to r3 and r5. Here, we describe the sequence and developmental expression of the Xenopus Krox-20 gene, XKrox-20. Alternating domains of XKrox-20 expression appear in the early neurula, later correspond to r3 and r5, and persist until late tadpole stages. In contrast to this conserved spatial expression in rhombomeres, we find a pattern in the neural crest of Xenopus that appears different from that found in the mouse: expression occurs in crest that migrates from r5 into the third visceral arch. We speculate that this may reflect a distinct route of neural crest migration due to anatomical differences between these systems, rather than a difference in the site of origin of Krox-20-expressing crest.
引用
收藏
页码:73 / 84
页数:12
相关论文
共 45 条
[1]  
ALTABA ARI, 1991, DEVELOPMENT, V112, P945
[2]   THE INFLUENCE OF THE METAMERIC PATTERN IN THE MESODERM ON MIGRATION OF CRANIAL NEURAL CREST CELLS IN THE CHICK-EMBRYO [J].
ANDERSON, CB ;
MEIER, S .
DEVELOPMENTAL BIOLOGY, 1981, 85 (02) :385-402
[3]  
[Anonymous], 1969, ERGEBN ANAT ENTWGESC
[4]   STRUCTURE, CHROMOSOME LOCATION, AND EXPRESSION OF THE MOUSE ZINC FINGER GENE KROX-20 - MULTIPLE GENE-PRODUCTS AND COREGULATION WITH THE PROTO-ONCOGENE C-FOS [J].
CHAVRIER, P ;
JANSSENTIMMEN, U ;
MATTEI, MG ;
ZERIAL, M ;
BRAVO, R ;
CHARNAY, P .
MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (02) :787-797
[5]   A GENE ENCODING A PROTEIN WITH ZINC FINGERS IS ACTIVATED DURING G0/G1 TRANSITION IN CULTURED-CELLS [J].
CHAVRIER, P ;
ZERIAL, M ;
LEMAIRE, P ;
ALMENDRAL, J ;
BRAVO, R ;
CHARNAY, P .
EMBO JOURNAL, 1988, 7 (01) :29-35
[6]   THE SEGMENT-SPECIFIC GENE KROX-20 ENCODES A TRANSCRIPTION FACTOR WITH BINDING-SITES IN THE PROMOTER REGION OF THE HOX-1.4 GENE [J].
CHAVRIER, P ;
VESQUE, C ;
GALLIOT, B ;
VIGNERON, M ;
DOLLE, P ;
DUBOULE, D ;
CHARNAY, P .
EMBO JOURNAL, 1990, 9 (04) :1209-1218
[7]   A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX [J].
DEVEREUX, J ;
HAEBERLI, P ;
SMITHIES, O .
NUCLEIC ACIDS RESEARCH, 1984, 12 (01) :387-395
[8]   SEGMENTATION IN THE CHICK-EMBRYO HINDBRAIN IS DEFINED BY CELL LINEAGE RESTRICTIONS [J].
FRASER, S ;
KEYNES, R ;
LUMSDEN, A .
NATURE, 1990, 344 (6265) :431-435
[9]  
GUTHRIE S, 1991, DEVELOPMENT, V112, P221
[10]   STUDIES ON TRANSFORMATION OF ESCHERICHIA-COLI WITH PLASMIDS [J].
HANAHAN, D .
JOURNAL OF MOLECULAR BIOLOGY, 1983, 166 (04) :557-580