TRIMETHOPRIM-SULFAMETHOXASOLE INDUCED MENINGITIS IN SYSTEMIC LUPUS-ERYTHEMATOSUS

Most reports of drug induced meningitis in systemic lupus erythematosus (SLE) have implicated ibuprofen. We describe a 46-year-old woman with SLE who developed aseptic meningitis abruptly after ingesting trimethoprim-sulfamethoxazole (TMP-SMX). This patient had received TMP-SMX twice before; each was associated with increasingly severe re-actions, whose relationship with the use of TMP-SMX became apparent only in retrospect. A history of medication use should be sought in all patients with meningitis who have an underlying autoimmune disorder.