NEURONAL DEVELOPMENT IN THE DROSOPHILA-RETINA - THE SEXTRA GENE DEFINES AN INHIBITORY COMPONENT IN THE DEVELOPMENTAL PATHWAY OF R7 PHOTORECEPTOR CELLS

被引：35
作者：
ROGGE, R
CAGAN, R
MAJUMDAR, A
DULANEY, T
BANERJEE, U
机构：
[1] UNIV CALIF LOS ANGELES,DEPT BIOL,LOS ANGELES,CA 90024
[2] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 12期
关键词：
EYE DEVELOPMENT; SEVENLESS;
D O I：
10.1073/pnas.89.12.5271
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Mutations in a gene called sextra (sxt) have been isolated. Loss of one copy of sxt promotes R7 photoreceptor cell development in a genetically sensitized background, while loss of both copies results in precursors of non-neuronal cone cells transforming into R7 cells. The requirement for sxt function is cell-autonomous. The transformation of cone-cell precursors into R7 cells occurs independently of the sevenless signal. However, the R7 precursor becomes neuronal in an sxt/sxt mutant only in a wild-type sevenless background. The genetic analysis of sxt suggests that it plays an inhibitory role, preventing cone cells from becoming neuronal. Additionally, sxt functions in R7 precursors, but the sevenless signal is essential for specification of this fate, since loss of sextra alone is unable to impart a neural fate to this cell.
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收藏
页码：5271 / 5275
页数：5
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