INVIVO EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN EXPERIMENTALLY INDUCED NEUROLOGIC DISEASES

被引：472
作者：
KOPROWSKI, H
ZHENG, YM
HEBERKATZ, E
FRASER, N
RORKE, L
FU, ZF
HANLON, C
DIETZSCHOLD, B
机构：
[1] CHILDRENS HOSP PHILADELPHIA,PHILADELPHIA,PA 19104
[2] WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 07期
关键词：
D O I：
10.1073/pnas.90.7.3024
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The purpose of this study was to investigate the induction of inducible nitric oxide synthase (iNOS) mRNA in the brain tissue of rats and mice under the following experimental conditions: in rats infected with borna disease virus and rabies virus, in mice infected with herpes simplex virus, and in rats after the induction of experimental allergic encephalitis. The results showed that iNOS mRNA, normally nondetectable in the brain, was present in animals after viral infection or after induction of experimental allergic encephalitis. The induction of iNOS mRNA coincided with the severity of clinical signs and in some cases with the presence of inflammatory cells in the brain. The results indicate that nitric oxide produced by cells induced by iNOS may be the toxic factor accounting for cell damage and this may open the door to approaches to the study of the pathogenesis of neurological diseases.
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页码：3024 / 3027
页数：4
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