SINGLE DOSE TOTAL LYMPHOID IRRADIATION COMBINED WITH CYCLOPHOSPHAMIDE AS IMMUNOSUPPRESSION FOR HUMAN MARROW TRANSPLANTATION IN APLASTIC-ANEMIA

被引：18

作者：

KIM, TH ^{[1
]}

KERSEY, JH ^{[1
]}

KHAN, FM ^{[1
]}

SEWCHAND, W ^{[1
]}

RAMSEY, N ^{[1
]}

KRIVIT, W ^{[1
]}

COCCIA, P ^{[1
]}

NESBIT, ME ^{[1
]}

LEVITT, SH ^{[1
]}

机构：

[1] UNIV MINNESOTA HOSP,DEPT PEDIAT,MINNEAPOLIS,MN 55455

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1979年 / 5卷 / 07期

关键词：

Aplastic anemia; Bone marrow transplantation; Total lymphoid irradiation;

D O I：

10.1016/0360-3016(79)90605-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Six patients with aplastic anemia underwent bone marrow transplantation following conditioning with high dose cyclophosphamide and single dose total lymphoid irradiation with 750 rad, 26 rad/min at the midplane of the patient. They all received bone marrow from human leukocyte antigens/mixed lymphocyte culture (HLA/MLC) matched siblings. Five of 6 patients were alive without complications at 12, 11, 7, 4 and 4 months respectively. The remaining patient died from sepsis which he had prior to transplantation. There were no graft rejection, graft-vs-Host Disease (GVHD) or interstitial pneumonitis among these patients. The procedure was well tolerated with minimal side effects. The results will be compared with those of groups whose bone marrow was previously transplanted with different immunosuppressive methods. © 1979.

引用

页码：993 / 996

页数：4

共 7 条

[1]

GRAZE PR, 1978, EXP HEMATOL, V6, P67

[2]

KERSEY JH, EXPT HEMATOLOGY TODA

[3] TOTAL-BODY IRRADIATION WITH A HIGH DOSE-RATE LINEAR-ACCELERATOR FOR BONE-MARROW TRANSPLANTATION IN APLASTIC-ANEMIA AND NEOPLASTIC DISEASE [J].