SENSITIZATION IN APLYSIA - RESTORATION OF TRANSMISSION IN SYNAPSES INACTIVATED BY LONG-TERM HABITUATION

被引:48
|
作者
CAREW, T [1 ]
CASTELLUCCI, VF [1 ]
KANDEL, ER [1 ]
机构
[1] COLUMBIA UNIV COLL PHYS & SURG, DEPT PSYCHIAT, DIV BEHAV, NEW YORK, NY 10032 USA
关键词
D O I
10.1126/science.451611
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Long-term habituation of a simple withdrawal reflex in Aplysia leads to an inactivation of synaptic transmission between identified sensory and gill motor neurons that persists for more than 3 weeks. A single sensitizing stimulus rapidly reactivates both the depressed behavioral response and the inactivated synaptic transmission. Thus sensitization, a simple competitive form of learning, provides a mechanism whereby changing environmental demands can rapidly override the long-term memory of habituation. Copyright © 1979 AAAS.
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页码:417 / 419
页数:3
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