BIOSYNTHESIS AND BIOLOGICAL-ACTIVITY OF LEUKOTRIENE-B4

被引：89
作者：
BORGEAT, P
NACCACHE, PH
机构：
[1] Inflammation and Immunology-Rheumatology Research Unit, Centre de Recherche du CHUL, Centre Hospitalier de l'Université Laval, 2705, Boulevard Laurier, Sainte-Foy, Québec
来源：
CLINICAL BIOCHEMISTRY | 1990年 / 23卷 / 05期
关键词：
arachidonic acid; inflammation; leukotriene; lipoxygenase; neutrophil; phagocyte; prostaglandin;
D O I：
10.1016/0009-9120(90)90272-V
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The leukotrienes are a family of biologically active molecules derived from arachidonic acid. While prostaglandins and thromboxanes are products of the cyclooxygenase pathway of arachidonic acid metabolism, the leukotrienes are formed by arachidonate 5-lipoxygenase, an enzyme present in phagocytes, mast cells, and basophils. Inflammatory stimuli, such as chemotactic peptides, platelet-activating factor, phagocytic particles, and immunological stimuli, which activate phagocytes and mast cells, stimulate leukotriene synthesis. Leukotriene B4, a dihydroxy derivative of arachidonic acid, has a unique stimulatory activity on important functional responses of phagocytes; leukotriene B4 exerts chemotactic and chemokinetic activity towards phagocytes in vitro and in vivo, and it is a putative mediator of inflammation. © 1990 The Canadian Society of Clinical Chemists.
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页码：459 / 468
页数：10
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