RENIN INHIBITORS - IMPROVEMENTS IN THE STABILITY AND BIOLOGICAL-ACTIVITY OF SMALL PEPTIDES CONTAINING NOVEL LEU-VAL REPLACEMENTS

被引：31

作者：

KLEINERT, HD ^{[1
]}

LULY, JR ^{[1
]}

MARCOTTE, PA ^{[1
]}

PERUN, TJ ^{[1
]}

PLATTNER, JJ ^{[1
]}

STEIN, H ^{[1
]}

机构：

[1] ABBOTT LABS,DIV CARDIOVASC RES,N CHICAGO,IL 60064

来源：

FEBS LETTERS | 1988年 / 230卷 / 1-2期

关键词：

D O I：

10.1016/0014-5793(88)80637-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：38 / 42

页数：5

共 17 条

[1] RENIN INHIBITORS - DIPEPTIDE ANALOGS OF ANGIOTENSINOGEN INCORPORATING TRANSITION-STATE, NONPEPTIDIC REPLACEMENTS AT THE SCISSILE BOND [J].

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[4]

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[5] MODIFIED PEPTIDES WHICH DISPLAY POTENT AND SPECIFIC-INHIBITION OF HUMAN RENIN [J].

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[6] NEW INHIBITORS OF HUMAN RENIN THAT CONTAIN NOVEL LEU-VAL REPLACEMENTS [J].

LULY, JR ;

YI, N ;

SODERQUIST, J ;

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[7]

LULY JR, 1986, Patent No. 189203

[8]

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[9]

LULY JR, 1986, Patent No. 229667

[10]

LULY JR, 1988, IN PRESS J MED CHEM

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