2,4-DIAMINO-5-BENZYLPYRIMIDINES AS ANTIBACTERIAL AGENTS .7. ANALYSIS OF THE EFFECT OF 3,5-DIALKYL SUBSTITUENT SIZE AND SHAPE ON BINDING TO 4 DIFFERENT DIHYDROFOLATE-REDUCTASE ENZYMES

被引：39

作者：

ROTH, B ^{[1
]}

RAUCKMAN, BS ^{[1
]}

FERONE, R ^{[1
]}

BACCANARI, DP ^{[1
]}

CHAMPNESS, JN ^{[1
]}

HYDE, RM ^{[1
]}

机构：

[1] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1987年 / 30卷 / 02期

关键词：

D O I：

10.1021/jm00385a017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：348 / 356

页数：9

共 35 条

[1]

BACCANARI DP, 1984, J BIOL CHEM, V259, P2291

[2] STRUCTURE ACTIVITY RELATIONSHIPS OF DIHYDROFOLATE-REDUCTASE INHIBITORS [J].

BLANEY, JM ;

HANSCH, C ;

SILIPO, C ;

VITTORIA, A .

CHEMICAL REVIEWS, 1984, 84 (04) :333-407

[3]

BOLIN JT, 1982, J BIOL CHEM, V257, P13650

[4] CRYSTALLOGRAPHIC INVESTIGATION OF THE COOPERATIVE INTERACTION BETWEEN TRIMETHOPRIM, REDUCED COFACTOR AND DIHYDROFOLATE-REDUCTASE [J].

CHAMPNESS, JN ;

STAMMERS, DK ;

BEDDELL, CR .

FEBS LETTERS, 1986, 199 (01) :61-67

[5] STUDIES IN THE QUINOLINE SERIES .3. SOME DERIVATIVES OF 4-STYRYLQUINOLINE [J].

CLAPP, MA ;

TIPSON, RS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1946, 68 (07) :1332-1334

[6]

CROUSE GF, 1982, J BIOL CHEM, V257, P7887

[7]

FERONE R, 1969, MOL PHARMACOL, V5, P49

[8] COMPARISON OF THE INHIBITION OF ESCHERICHIA-COLI AND LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE BY 2,4-DIAMINO-5-(SUBSTITUTED-BENZYL)PYRIMIDINES - QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS, X-RAY CRYSTALLOGRAPHY, AND COMPUTER-GRAPHICS IN STRUCTURE ACTIVITY ANALYSIS [J].

HANSCH, C ;

LI, RL ;

BLANEY, JM ;

LANGRIDGE, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (07) :777-784

[9] EFFECT OF SUBSTRATE DECOMPOSITION ON SPECTROPHOTOMETRIC ASSAY OF DIHYDROFOLATE REDUCTASE [J].

HILLCOAT, BL ;

NIXON, PF ;

BLAKLEY, RL .

ANALYTICAL BIOCHEMISTRY, 1967, 21 (02) :178-&

[10]

HYDE RM, 1982, STRATEGY DRUG RES, P385

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