PENTOXIFYLLINE-ASSOCIATED REDUCTION OF INDOMETHACIN-INDUCED RAT GASTRIC-MUCOSAL INJURY IS SUPPORTED BY DECREASED LIPID-PEROXIDATION

被引：0
作者：
SALLINGOVA, Z
KOHUT, A
机构：
来源：
PHYSIOLOGICAL RESEARCH | 1994年 / 43卷 / 02期
关键词：
PENTOXIFYLLINE; INDOMETHACIN; GASTRIC LESIONS; ACTIVATED NEUTROPHILS; LIPID PEROXIDATION; RAT;
D O I：
暂无
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Pentoxifylline pretreatment protects rat gastric mucosa against indomethacin-induced damage. Lipid peroxidation after indomethacin treatment (determined as thiobarbituric acid reactants) was significantly reduced by a single dose of pentoxifylline. The same was true for pentoxifylline administration for 6 days. There is a relationship between reduced lipid peroxidation, decreased number of circulating activated neutrophils and diminished disposition for acute gastric mucosal lesions induced by indomethacin in pentoxifylline-pretreated rats.
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页码：95 / 99
页数：5
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