EFFECT OF DES-TYROSINE-GAMMA-ENDORPHIN ON NEOCORTICAL SPIKE-AND-WAVE SPINDLING IN DBA/2J MICE

被引：4

作者：

CAPASSO, A ^{[1
]}

SORRENTINO, L ^{[1
]}

DIGIANNUARIO, A ^{[1
]}

PIERETTI, S ^{[1
]}

LOIZZO, A ^{[1
]}

机构：

[1] IST SUPER SANITA,ROME,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 261卷 / 1-2期

关键词：

BETA-ENDORPHIN FRAGMENT; NEOCORTICAL SPIKE-AND-WAVE SPINDLING; ELECTROCORTICOGRAM; DBA/2J MOUSE;

D O I：

10.1016/0014-2999(94)90321-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of a beta-endorphin cleavage product devoid of opioid effects, des-tyrosine-gamma-endorphin (DT gamma E) on the neocortical spike-and-wave spindling episodes in the electrocorticogram (ECoG) of DBA/2J mice was studied. DT gamma E (0.01-1.0 mg/kg, i.p.) dose dependently reduced the spike-and-wave bursts duration. However, the low dose did not induce consistent modifications of the spike-and-wave bursts number while the dose of 0.1 and 1.0 mg/kg induced a progressive diminution. Furthermore, at all doses DT gamma E did not induce any alterations of the spike-and-wave bursts amplitude, frequency, and desynchronized activity when compared to the pre-drug period. These results indicate that this beta-endorphin fragment may affect brain excitability.

引用

页码：209 / 212

页数：4

共 15 条

[1] DEXAMETHASONE AND HORMONES RELATED TO THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS MODULATE INHERITED NEOCORTICAL SPINDLING IN DBA/2J MICE [J].