THE INFLUENCE OF MATERNAL NICOTINE EXPOSURE ON THE INTERALVEOLAR SEPTAL STATUS OF NEONATAL RAT LUNG

被引：16
作者：
MARITZ, GS
THOMAS, RA
机构：
[1] Department of Physiological Sciences, University of the Western Cape, Bellville
来源：
CELL BIOLOGY INTERNATIONAL | 1994年 / 18卷 / 07期
关键词：
D O I：
10.1006/cbir.1994.1104
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The aim of this study was to determine the effect of maternal nicotine exposure (1 mg nicotine/kg body mass/day, subcutaneously) on the status of the alveolar septa of the 1 to 21 day old offspring. The data obtained showed swelling of type II and interstitial cell mitochondria. The type I:type II cell ratio decreased as a result of type m cell proliferation. The number of capillaries per unit length of septum was also significantly lower than that of control lung. Ruptured blood-air barriers also occur in the nicotine exposed lungs of rats of all age groups. The results show that maternal nicotine exposure interfered with the morphometric and morphologic characteristics of the septa of lung tissue of the offspring.
引用
收藏
页码：747 / 757
页数：11
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