BENZODIAZEPINE RECEPTOR MEDIATION OF THE ANXIOLYTIC-LIKE EFFECT OF (-)-NICOTINE IN MICE

被引：36

作者：

ONEILL, AB ^{[1
]}

BRIONI, JD ^{[1
]}

机构：

[1] ABBOTT LABS,DIV PHARMACEUT PROD,NEUROSCI RES,ABBOTT PK,IL 60064

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 49卷 / 03期

关键词：

NICOTINE; DIAZEPAM; ANXIETY;

D O I：

10.1016/0091-3057(94)90097-3

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The anxiolytic-like effect of (-)-nicotine (1.9 mu mol/kg, IP) on the elevated plus-maze in CD1 mice was blocked by the benzodiazepine receptor antagonist flumazenil (1 and 10 mu mol/kg, IP). On the other hand, the cholinergic nicotinic channel blocker mecamylamine (1 to 15 mu mol/kg, IP), did not affect the anxiolytic-like properties of diazepam in the same test. These data suggest that the reduction in anxiety induced by (-)-nicotine occurs indirectly via the release of endogenous substances than can activate the benzodiazepine receptor.

引用

页码：755 / 757

页数：3

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