DIASTEREOSELECTIVE ELECTROPHILIC AMINATION OF KETONE ENOLATES IN 2-SUBSTITUTED 2-ACYL-1,3-DITHIANE 1-OXIDES

被引：18
作者：
PAGE, PCB [1 ]
ALLIN, SM [1 ]
COLLINGTON, EW [1 ]
CARR, RAE [1 ]
机构：
[1] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 15期
关键词：
D O I：
10.1016/0040-4039(94)85237-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Enolate anions derived from 2-substituted 2-acyl-1,3-dithiane 1-oxides react readily with the nitrogen electrophile di-tert-butyl azodicarboxylate (DBAD) to give alpha-aminoketones with good diastereoselectivity and in reasonable yields; in some cases diastereoselectivity appears sufficiently high that the minor isomer cannot be detected by 400 MHz H-1 NMR spectroscopy.
引用
收藏
页码：2427 / 2430
页数：4
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