EARLY CYTOKINE RESPONSE TO MULTIPLE INJURY

被引：31
作者：
FOEX, BA
LAMB, WR
ROBERTS, TE
BREAR, SG
MACARTNEY, I
HAMMER, M
BRENCHLEY, PEC
机构：
[1] Department of Intensive Care, North Manchester General Hospital, Manchester
[2] Department of Biochemistry, North Manchester General Hospital, Manchester
[3] Department of Immunology, St Mary's Hospital, Manchester
来源：
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | 1993年 / 24卷 / 06期
关键词：
D O I：
10.1016/0020-1383(93)90098-Q
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Serial measurements of the inflammatory cytokines interleukin 6 (IL-6) and tumour necrosis factor alpha (TNFalpha) were made in four patients with multiple injuries to characterize secretion patterns and to relate them to severity of injury and degree of haemorrhage. IL-6 and TNFalpha were assayed using a sandwich ELISA. Injury scores varied from 9 to 50, and transfusion requirements varied from 7 to 14 units. All patients showed an increase in IL-6 but only one a rise in TFNalpha. There was no consistent pattern in the elevation of IL-6 and there was no relation between cytokine levels, severity of injury, transfusion requirement or ultimate outcome. From this preliminary study it would seem that measurement of IL-6 and TNFalpha is not of value in directing therapeutic decisions or as a predictor of outcome.
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收藏
页码：373 / 376
页数：4
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