IMMUNOSUPPRESSIVE THERAPY OF AUTOIMMUNE-DISEASES (REPRINTED FROM TRENDS IN PHARMACOLOGICAL SCIENCES, VOL 14, PG 213-217, 1993)

被引：47
作者：
BACH, JF
机构：
来源：
IMMUNOLOGY TODAY | 1993年 / 14卷 / 06期
关键词：
D O I：
10.1016/0167-5699(93)90053-N
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cyclosporin A, corticosteroids and cyclophosphamide show a remarkable efficacy in a large number of autoimmune diseases. However, their effect is dependent on continuous drug administration with potential risks of drug toxicity and over immunosuppression. Results recently obtained in animal models, particularly with anti-CD3 and anti-CD4 monoclonal antibodies, indicate that reestablishment of tolerance to self antigens is a feasible goal.
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页码：322 / 326
页数：5
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