NUCLEOSIDES AND NUCLEOTIDES .106. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 1-(2-DEOXY-2-HYDROXYIMINO-BETA-D-ERYTHRO-PENTOFURANOSYL)-THYMINE OR METHOXYIMINO-BETA-D-ERYTHRO-PENTOFURANOSYL)-THYMINE AND METHOXYIMINO-BETA-D-ERYTHRO-PENTOFURANOSYL)-CYTOSINE

被引：3

作者：

MATSUDA, A ^{[1
]}

NAKAJIMA, Y ^{[1
]}

UEDA, T ^{[1
]}

SASAKI, T ^{[1
]}

机构：

[1] KANAZAWA UNIV,CANC RES INST,KANAZAWA,ISHIKAWA 920,JAPAN

来源：

NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 2-4期

关键词：

D O I：

10.1080/07328319208021699

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reaction of 1-(3,5-0-tetraisopropyldisiloxan-1,3-diyl-beta-D-erythro-2-pento-furan-2-ulosyl)uracil (8) with hydroxylamine hydrochloride in pyridine at room temperature for 24 h or at 80-degrees-C for 3 h gives the 2'-deoxy-2'-hydroxyiminouridine derivative 9 in good yield. Similarly, oximation of 8 with methoxyamine has been done to obtain 2'-deoxy-2'-methoxyimino derivatives 11 in a high yield. Compound 9 was converted into 1-(2-deoxy-2-hydroxyimino-beta-D-erythro-pentofuranosyl)cytosine (3). Cytotoxicity in vitro of these nucleosides against murine leukemia L1210 cells was also examined.

引用

页码：237 / 246

页数：10

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