DISTRIBUTION IN TISSUE-SECTIONS OF THE HUMAN GROEL STRESS-PROTEIN HOMOLOG

被引：63
作者：
EVANS, DJ
NORTON, P
IVANYI, J
机构：
[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,MRC,TB & RELATED INFECT UNIT,LONDON W12 0HS,ENGLAND
[2] ST MARYS HOSP,SCH MED,DEPT HISTOPATHOL,LONDON,ENGLAND
来源：
APMIS | 1990年 / 98卷 / 05期
关键词：
Immunohistology; Mitochondrion; Stress proteins;
D O I：
10.1111/j.1699-0463.1990.tb01055.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A monoclonal antibody (ML30) raised against the 65 kDa heat-shock protein of mycobacteria showed widespread staining of sections from standard paraffin-embedded human tissues. The staining had a granular pattern and was particularly marked in cells with abundant mitochondria. Increased staining was observed in the synovial lining, histocytes and in the endothelium of reactive and rheumatoid synovium; it was also increased in the reactive lung alveolar lining. It is suggested that the antibody identifies an epitope in mitochondria of a protein homologous with the groEL heat-shock protein of bacteria.
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页码：437 / 441
页数：5
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