ENDOCYTIC VESICLES CONTAIN A CALMODULIN-ACTIVATED CA-2+ PUMP THAT MEDIATES THE INHIBITION OF ACIDIFICATION BY CALCIUM

被引：13
|
作者：
NUNEZ, MT
GAETE, V
ESCOBAR, A
机构：
[1] Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Santiago
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1028卷 / 01期
基金：
美国国家科学基金会;
关键词：
Acidification; Calcium ion; Calcium pump; Calmodulin; Endocytic vesicle; pH;
D O I：
10.1016/0005-2736(90)90260-U
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endocytic vesicles isolated from rabbit reticulocytes contained an intrinsic Ca2+-pump activity that was dependent on ATP, activated by calmodulin and inhibited by vanadate. 45Ca2+ uptake and acidification studies indicated that acidification of the endocytic vesicles inversely correlated with the Ca2+-pump activity. Acidification was inhibited by externally added Ca2+ and calmodulin and activated by vanadate and EGTA. It is suggested that intravesicular Ca2+ can act as a modulator of endocytic vesicle acidification. © 1990.
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页码：21 / 24
页数：4
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