News and views on EMT Fra-1 controls EMT in mammary epithelial cells

被引：1

作者：

Bakiri, Latifa ^{[1
]}

Wagner, Erwin F. ^{[1
]}

机构：

[1] Natl Canc Res Ctr CNIO, F BBVA CNIO Canc Cell Biol Program, Genes Dev & Dis Grp, Madrid, Spain

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 03期

基金：

欧洲研究理事会;

关键词：

EpH4; Zeb1; Zeb2; E-cadherin; tumorigenesis; metastasis;

D O I：

10.4161/23723556.2014.990307

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epithelial-to-mesenchymal transition (EMT), a process critical for breast cancer cell dissemination, engages the Fos-related antigen 1 (Fra-1) transcription factor. Molecular and cellular analyses revealed an evolutionary conservation of Fra-1 functions in EMT of mouse and human mammary cells, establishing a solid basis for preclinical studies in genetically engineered mouse models.

引用

页数：3

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