MUTAGENICITY OF AMINO-ALPHA-CARBOLINES IN PYROLYSIS PRODUCTS OF SOYBEAN GLOBULIN

被引：177

作者：

YOSHIDA, D ^{[1
]}

MATSUMOTO, T ^{[1
]}

YOSHIMURA, R ^{[1
]}

MATSUZAKI, T ^{[1
]}

机构：

[1] MITSUBISHI KASEI INST TOXICOL & ENVIRONM SCI,MIDORI KU,YOKOHAMA 227,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1978年 / 83卷 / 03期

关键词：

D O I：

10.1016/0006-291X(78)91482-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2-amino-9H-pyrido[2,3-b]indole and 2-amino-3-methyl-9H-pyrido [2,3-b]indole (amino-α-carbolines), potent mutagens toward Salmonella typhimurium TA 98 and TA 100, have been isolated from the pyrolysis products of soybean globulin and the structures have been established by X-ray analysis. 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (amino-↔-carbolines) identified as the mutagenic principles in tryptophan pyrolyzate were not detected in the pyrolysis products of soybean globulin. © 1978.

引用

页码：915 / 920

页数：6

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