ROLE OF ENDOTHELIN IN SPONTANEOUS PHASIC CONTRACTION OF HUMAN CORONARY-ARTERIES

被引：0

作者：

DAGASSAN, PH ^{[1
]}

CLOZEL, M ^{[1
]}

BREU, V ^{[1
]}

CLOZEL, JP ^{[1
]}

机构：

[1] F HOFFMANN LA ROCHE & CO LTD,DIV PHARMA,PRECLIN RES,CH-4002 BASEL,SWITZERLAND

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1995年 / 26卷

关键词：

BOSENTAN; BQ-123; CORONARY ARTERIES; ENDOTHELIN; HUMAN; SPONTANEOUS PHASIC CONTRACTIONS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Isolated human coronary arteries are known to develop spontaneous phasic contractions (SPCs). The goal of the present study was to assess the role of endothelin (ET) in these contractions. Endothelium-denuded rings from left anterior descending (LAD) coronary arteries of patients with coronary artery disease (CAD; n = 3) undergoing cardiac transplantation developed SPCs within 1-2 h. The contractions were abolished by the ET(A) receptor antagonist BQ-123 or the mixed ET receptor antagonist bosentan (1 and 3 mu M), whereas the contractions persisted for several hours in control rings. Exogenous ET-1 (10 pM) increased the amplitude of SPCs and initiated SPCs in rings that did not exhibit SPCs. Higher concentrations of ET-1 (greater than or equal to 1 nM) were able to re-induce SPC in rings in which SPCs had been abolished by BQ-123 or bosentan. These results suggest that ET plays an important role in spontaneous phasic contractions of isolated human coronary artery rings.

引用

页码：S200 / S203

页数：4

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