THE BIOCHEMICAL-MECHANISMS OF THE TOXIC EFFECTS OF SOME PYRIDINE-DERIVATIVES .1. STUDY ON THE DEAMINATION OF BIOGENIC-AMINES AND OTHER NITROGENOUS COMPOUNDS IN PARAQUAT INTOXICATION

被引：2

作者：

GORKIN, V ^{[1
]}

AMANOV, K ^{[1
]}

MAMADIEV, M ^{[1
]}

MEDVEDEV, A ^{[1
]}

KHUZHAMBERDIEV, M ^{[1
]}

机构：

[1] MED SCH,ANDIZHAN,UZBEKISTAN

来源：

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 1994年 / 26卷 / 04期

关键词：

D O I：

10.1007/BF00214158

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Lethal intoxication of rats with the herbicide paraquat (1,1'-dimethyl-4,4'-bipyridilium dichloride) caused a stimulation of lipid peroxidation (LPO) in lung, brain, heart, liver, and kidney. Treatment of animals with antioxidant diludin (2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine) or with the reductants sodium ascorbate or thiosulphate normalized the rate of LPO in these tissues and decreased mortality of intoxicated rats. The development of lethal paraquat intoxication was accompanied by a decrease of the deamination of monoamine oxidase (MAO) substrates serotonin, tryptamine, benzylamine, and tyramine in mitochondria of organs studied with simultaneous stimulation or appearance of deamination of glucosamine, gamma-aminobutyric acid (GABA), putrescine, and L-lysine. The alterations in deamination of the nitrogenous compounds caused by paraquat were also reversed by treatment of animals with antioxidant or reductants. The data obtained support a hypothesis of an involvement of modification in catalytic properties of MAOs in the pathogenesis of paraquat intoxication.

引用

页码：534 / 539

页数：6

共 35 条

[1] BIOCHEMICAL-MECHANISMS OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE TOXICITY - COULD OXIDATIVE STRESS BE INVOLVED IN THE BRAIN [J].