DECREASED LEVELS OF SOLUBLE AMYLOID BETA-PROTEIN PRECURSOR ARE ASSOCIATED WITH ALZHEIMERS-DISEASE IN CONCORDANT AND DISCORDANT MONOZYGOTIC TWIN PAIRS

被引：16

作者：

WAGNER, SL

PESKIND, ER

NOCHLIN, D

PROVOW, S

FARROW, JS

PANDIAN, MR

CLEVELAND, M

ITO, RK

FARLOW, MR

机构：

[1] UNIV WASHINGTON,SCH MED,DEPT PSYCHIAT & BEHAV SCI,SEATTLE,WA 98195

[2] UNIV WASHINGTON,SCH MED,DEPT PATHOL,SEATTLE,WA 98195

[3] AMER LAKE VET AFFAIRS MED CTR,SEATTLE,WA

[4] NICHOLS INST,SAN JUAN CAPISTRANO,CA

[5] INDIANA UNIV,SCH MED,DEPT NEUROL,INDIANAPOLIS,IN 46202

[6] VET AFFAIRS MED CTR,SEATTLE,WA

来源：

ANNALS OF NEUROLOGY | 1994年 / 36卷 / 02期

关键词：

D O I：

10.1002/ana.410360214

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We conducted immunochemical measurements of soluble amyloid beta-protein precursor (beta PP) in cerebrospinal fluid (CSF) from three monozygous twin pairs. Two of the twin pairs are discordant for Alzheimer's disease and one pair showed concordance for Alzheimer's disease, which was confirmed neuropathologically. All affected individuals displayed substantially lower levels of soluble beta PP in CSF compared with the unaffected individuals. There were no differences in total protein levels in CSF samples from the affected twins compared with those of the unaffected twins. These studies suggest that decreased soluble beta PP in CSF may reflect neuropathological processes in Alzheimer's disease involving beta PP.

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页码：215 / 220

页数：6

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