RIBOFLAVIN DEFICIENCY CAUSED BY TREATMENT WITH ADRIAMYCIN

被引：0
|
作者：
OGURA, R
UETA, H
HINO, Y
HIDAKA, T
SUGIYAMA, M
机构：
来源：
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY | 1991年 / 37卷 / 05期
关键词：
RIBOFLAVIN; ADRIAMYCIN; GLUTATHIONE REDUCTASE; LIPID PEROXIDE; URINARY EXCRETION; HEART MITOCHONDRIA;
D O I：
暂无
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The present study was undertaken to determine whether administration of adriamycin causes the depletion of riboflavin content. Rats received intraperitoneal injections of adriamycin (4 mg per kg body weight) for 6 consecutive days. Urinary riboflavin excretion began to increase after 2 days of treatment with adriamycin. Erythrocyte FAD levels decreased gradually and plasma lipid peroxide contents increased markedly at the 6th day. The activity coefficient of erythrocyte glutathione reductase showed a significant increase before the decrease of flavin content and the elevation of lipid peroxide level. Therefore, the value of this coefficient obtained from erythrocyte appears to be a reliable index of riboflavin deficiency, particularly during the early stage.
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页码：473 / 477
页数：5
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