IS SUBSTANCE-P RELEASED FROM SLICES OF THE RAT SPINAL-CORD INACTIVATED BY PEPTIDASE(S) DISTINCT FROM BOTH ENKEPHALINASE AND ANGIOTENSIN-CONVERTING ENZYME

被引:30
作者
MAUBORGNE, A
BOURGOIN, S
BENOLIEL, JJ
HAMON, M
CESSELIN, F
机构
[1] INSERM U 288, Faculté de Médecine Pitié-Salpêtrière, Paris
关键词
SUBSTANCE-P-LIKE IMMUNOREACTIVE MATERIAL; RAT SPINAL CORD; K+-INDUCED RELEASE; BACITRACIN; CAPTOPRIL; ENALAPRILAT; KELATORPHAN; THIORPHAN;
D O I
10.1016/0304-3940(91)90935-M
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Studies on the effects of peptidase inhibitors on substance P-like immunoreactive material (SPLI) released by K+ -induced depolarization from slices of the rat spinal cord showed that bacitracin was the most potent agent to protect SPLI from degradation. Captopril and thiorphan which inhibit, respectively, angiotensin I converting enzyme and endopeptidase-24.11 also protected SPLI from degradation. However other inhibitors of these two enzymes, kelatorphan for endopeptidase-24.11 and enalaprilat for angiotensin I converting enzyme were essentially inactive, indicating that both enzymes are probably not involved in the degradation of endogenous substance P. Instead, the non-additive protecting effect of bacitracin, captopril and thiorphan might be due to the blockade of some 'bacitracin-sensitive enzyme' playing a key role in the catabolism of SP within the rat spinal cord.
引用
收藏
页码:221 / 225
页数:5
相关论文
共 20 条
[1]   BIDENTATE PEPTIDES - HIGHLY POTENT NEW INHIBITORS OF ENKEPHALIN DEGRADING ENZYMES [J].
BOUBOUTOU, R ;
WAKSMAN, G ;
DEVIN, J ;
FOURNIEZALUSKI, MC ;
ROQUES, BP .
LIFE SCIENCES, 1984, 35 (09) :1023-1030
[2]  
BOURGOIN S, 1986, J PHARMACOL EXP THER, V238, P360
[3]   PURIFICATION AND CHARACTERIZATION OF ENKEPHALINASE, ANGIOTENSIN CONVERTING ENZYME, AND A 3RD PEPTIDYLDIPEPTIDASE FROM RAT-BRAIN [J].
CUSHMAN, DW ;
GORDON, EM ;
WANG, FL ;
CHEUNG, HS ;
TUNG, R ;
DELANEY, NG .
LIFE SCIENCES, 1983, 33 :25-28
[4]   PURIFICATION AND CHARACTERIZATION OF A SUBSTANCE-P-DEGRADING ENDOPEPTIDASE FROM RAT-BRAIN [J].
ENDO, S ;
YOKOSAWA, H ;
ISHII, S .
JOURNAL OF BIOCHEMISTRY, 1988, 104 (06) :999-1006
[5]  
HEYMAN E, 1978, FEBS LETT, V114, P360
[6]   DEGRADATION OF SUBSTANCE-P BY NEURONS AND GLIAL-CELLS [J].
HORSTHEMKE, B ;
SCHULZ, M ;
BAUER, K .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 125 (02) :728-733
[7]   OPIATE ANALGESICS INHIBIT SUBSTANCE - P RELEASE FROM RAT TRIGEMINAL NUCLEUS [J].
JESSELL, TM ;
IVERSEN, LL .
NATURE, 1977, 268 (5620) :549-551
[8]   PURIFICATION AND CHARACTERIZATION OF A MEMBRANE-BOUND SUBSTANCE-P-DEGRADING ENZYME FROM HUMAN-BRAIN [J].
LEE, CM ;
SANDBERG, BEB ;
HANLEY, MR ;
IVERSEN, LL .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1981, 114 (02) :315-327
[9]   NEUROPEPTIDES AND THEIR PEPTIDASES - FUNCTIONAL CONSIDERATIONS [J].
LITTLEWOOD, GM ;
IVERSEN, LL ;
TURNER, AJ .
NEUROCHEMISTRY INTERNATIONAL, 1988, 12 (03) :383-389
[10]   SUBSTANCE-P AND [LEU]ENKEPHALIN ARE HYDROLYZED BY AN ENZYME IN PIG CAUDATE SYNAPTIC-MEMBRANES THAT IS IDENTICAL WITH THE ENDOPEPTIDASE OF KIDNEY MICROVILLI [J].
MATSAS, R ;
FULCHER, IS ;
KENNY, AJ ;
TURNER, AJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (10) :3111-3115