Pharmacological perspectives in sarcopenia: a potential role for renin-angiotensin system blockers?

被引：22

作者：

Sartiani, Laura ^{[1
]}

Spinelli, Valentina ^{[1
]}

Laurino, Annunziatina ^{[1
]}

Blescia, Sabrina ^{[1
]}

Raimondi, Laura ^{[1
]}

Cerbai, Elisabetta ^{[1
]}

Mugelli, Alessandro ^{[1
]}

机构：

[1] Univ Florence, Ctr Mol Medi CIMMBA, Dept Neurosci Psychol Drug Res & Child Hlth Neuro, Viale G Pieraccini 6, I-50139 Florence, Italy

来源：

CLINICAL CASES IN MINERAL AND BONE METABOLISM | 2015年 / 12卷 / 02期

关键词：

sarcopenia; skeletal muscle; angiotensin; angiotensin-converting enzyme inhibitors; angiotensin receptors blockers;

D O I：

10.11138/ccmbm/2015.12.2.135

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sarcopenia represents a major health problem highly prevalent in elderly and age-related chronic diseases. Current pharmacological strategies available to prevent and reverse sarcopenia are largely unsatisfactory thus raising the need to identify novel targets for pharmacological intervention and possibly more effective and safe drugs. This review highlights the current knowledge of the potential benefits of renin-angiotensin system blockade in sarcopenia and discuss the main mechanisms underlying the effects.

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收藏

页码：135 / 138

页数：4

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