CYCLIC-GMP AND THE PERMEABILITY OF THE DISKS OF THE FROG PHOTORECEPTORS

被引：43

作者：

CARETTA, A ^{[1
]}

CAVAGGIONI, A ^{[1
]}

SORBI, RT ^{[1
]}

机构：

[1] UNIV PARMA, IST FISIOL UMANA, I-43100 PARMA, ITALY

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 1979年 / 295卷 / OCT期

关键词：

D O I：

10.1113/jphysiol.1979.sp012959

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The diffusion of Na, K and Rb (not Cl-) ions across the disk membrane is increased by cyclic [c]GMP. The increase is greater for Na than for Rb in the 0.01-0.1 mM concentration range. Cyclic AMP is less efficient than cGMP; GMP and GTP are without effect. The effect is present with 1.8 mM Ca ions or 4 mM-EGTA [ethylene glycol-bis-(.beta.-aminoethyl ether) N,N,N'',N''-tetraacetic acid] in the perfusion fluid. The presence of the cGMP phosphodiesterase on the disc membranes is not needed for this effect. The effect is present in unbleached and fully bleached membranes.

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页码：171 / 178

页数：8

相关论文

共 13 条

[1] LIGHT-ACTIVATED HYDROLYSIS OF GTP AND CYCLIC-GMP IN ROD OUTER SEGMENTS [J].

BIGNETTI, E ;

CAVAGGIONI, A ;

SORBI, RT .

JOURNAL OF PHYSIOLOGY-LONDON, 1978, 279 (JUN) :55-69

[2]

BITENSKY MW, 1978, ADV CYCLIC NUCLEOTID, V9

[3] LIGHT-SENSITIVE SWELLING OF ISOLATED FROG ROD OUTER SEGMENTS AS AN INVITRO ASSAY FOR VISUAL TRANSDUCTION AND DARK-ADAPTATION [J].

BOWNDS, D ;

BRODIE, AE .

JOURNAL OF GENERAL PHYSIOLOGY, 1975, 66 (04) :407-425

[4] BIOCHEMICAL CORRELATES OF ADAPTATION PROCESSES IN ISOLATED FROG PHOTORECEPTOR MEMBRANES [J].

BRODIE, AE ;

BOWNDS, D .

JOURNAL OF GENERAL PHYSIOLOGY, 1976, 68 (01) :1-11

[5]

CARETTA A, 1976, J PHYSL, V257, P687

[6] EFFLUX OF POTASSIUM FROM ISOLATED ROD OUTER SEGMENTS - PHOTIC EFFECT [J].

CAVAGGIO.A ;

SORBI, RT ;

TURINI, S .

JOURNAL OF PHYSIOLOGY-LONDON, 1973, 232 (03) :609-620

[7] LIGHT ACTIVATION OF PHOSPHODIESTERASE ACTIVITY IN RETINAL ROD OUTER SEGMENTS [J].

CHADER, GJ ;

HERZ, LR ;

FLETCHER, RT .

BIOCHIMICA ET BIOPHYSICA ACTA, 1974, 347 (03) :491-493

[8] LIGHT-REGULATED GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE OF BOVINE RETINA [J].

GORIDIS, C ;

VIRMAUX, N .

NATURE, 1974, 248 (5443) :57-58

[9] EFFECTS OF LIGHT ON CYCLIC-GMP METABOLISM IN RETINAL PHOTORECEPTORS [J].

KRISHNA, G ;

KRISHNAN, N ;

FLETCHER, RT ;

CHADER, G .

JOURNAL OF NEUROCHEMISTRY, 1976, 27 (03) :717-&

[10] REGULATION OF CYCLIC NUCLEOTIDE CONCENTRATIONS IN PHOTORECEPTORS - ATP-DEPENDENT STIMULATION OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE BY LIGHT [J].

MIKI, N ;

KEIRNS, JJ ;

MARCUS, FR ;

FREEMAN, J ;

BITENSKY, MW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (12) :3820-3824