Differences in structural elements of Bcr-Abl oncoprotein isoforms in Chronic Myelogenous Leukemia

被引：25

作者：

Hai, Abdul ^{[1
]}

Kizilbash, Nadeem A. ^{[1
]}

Zaidi, Syeda Huma H. ^{[2
]}

Alruwaili, Jamal ^{[1
]}

Shahzad, Khuram ^{[3
]}

机构：

[1] Northern Border Univ, Fac Med & Appl Med Sci, Dept Biochem, Ar Ar, Saudi Arabia

[2] Northern Border Univ, Dept Chem, Fac Sci, Ar Ar 91431, Saudi Arabia

[3] Univ Illinois, Illinois Informat Inst, Urbana, IL 61801 USA

来源：

BIOINFORMATION | 2014年 / 10卷 / 03期

关键词：

D O I：

10.6026/97320630010108

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In silico modeling, using Psipred and ExPASy servers was employed to determine the structural elements of Bcr-Abl oncoprotein (p210(BCR-ABL)) isoforms, b2a2 and b3a2, expressed in Chronic Myelogenous Leukemia (CML). Both these proteins are tyrosine kinases having masses of 210-kDa and differing only by 25 amino acids coded by the b3 exonand an amino acidsubstitution (Glu903Asp). The secondary structure elements of the two proteins show differences in five alpha-helices and nine beta-strands which relates to differences in the SH3, SH2, SH1 and DNA-binding domains. These differences can result in different roles played by the two isoforms in mediating signal transduction during the course of CML.

引用

页码：108 / 114

页数：7

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