CHEMOTHERAPY OF ADVANCED SMALL-CELL ANAPLASTIC CARCINOMA - SUPERIORITY OF A 4-DRUG COMBINATION TO A 3-DRUG COMBINATION

被引：116

作者：

HANSEN, HH ^{[1
]}

DOMBERNOWSKY, P ^{[1
]}

HANSEN, M ^{[1
]}

HIRSCH, F ^{[1
]}

机构：

[1] BISPEBJERG HOSP, DEPT MED C, DK-2400 COPENHAGEN, DENMARK

来源：

ANNALS OF INTERNAL MEDICINE | 1978年 / 89卷 / 02期

关键词：

D O I：

10.7326/0003-4819-89-2-177

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A controlled clinical trial compared three-drug and four-drug combination chemotherapy in 109 patients with advanced small-cell anaplastic carcinoma of the lung. The combination of vincristine, 1-(2-chloroethyl)-3-cyclohexyl- 1-nitrosourea (CCNU), cyclophosphamide, and methotrexate was significantly superior to the combination of the last three drugs alone with regard to median survival (230 versus 176 days) (P<0.01) and to duration of response (186 versus 112 days) (P<0.01). Objective response occurred in 78% and 75%, respectively. No significant difference in these values was observed in the comparison of the three subtypes of small-cell anaplastic carcinoma using the World Health Organization's classification.

引用

页码：177 / 181

页数：5

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