DIFFERENTIAL EXPRESSION OF C-FOS AND C-JUN IN 2 REGIONS OF THE RAT SPINAL-CORD FOLLOWING NOXIOUS COLORECTAL DISTENSION

被引：66

作者：

TRAUB, RJ ^{[1
]}

HERDEGEN, T ^{[1
]}

GEBHART, GF ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST PHYSIOL 1,W-6900 HEIDELBERG,GERMANY

来源：

NEUROSCIENCE LETTERS | 1993年 / 160卷 / 02期

关键词：

VISCERAL PAIN; DORSAL HORN; SYMPATHETIC; PARASYMPATHETIC; IMMEDIATE-EARLY GENE;

D O I：

10.1016/0304-3940(93)90394-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Thoracolumbar and lumbosacral spinal segments that receive afferent input from the descending colon and rectum were stained immunocytochemically for c-Fos- and c-Jun-like proteins following repetitive, noxious colorectal distention (CRD). Noxious CRD (80 mmHg) resulted in significantly more c-Fos- and c-Jun-like immunoreactivity in the sacral dorsal horn than in the thoracic dorsal horn. In both regions of the spinal cord the increase in c-Fos-like immunoreactivity was at least twice that of c-Jun-like immunoreactivity. Basal levels of c-Jun but not c-Fos were observed in the thoracic intermediolateral nucleus (IML) and the sacral parasympathetic nucleus (SPN). Noxious CRD induced both c-Fos and c-Jun in the SPN, but not the IML.

引用

页码：121 / 125

页数：5

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