QUANTITATIVE-TRAIT-LOCI (QTL) ANALYSES AND ALCOHOL-RELATED BEHAVIORS

被引：67

作者：

PLOMIN, R ^{[1
]}

MCCLEARN, GE ^{[1
]}

机构：

[1] PENN STATE UNIV,COLL HLTH & HUMAN DEV,BIOBEHAV HLTH PROGRAM,UNIV PK,PA 16802

来源：

BEHAVIOR GENETICS | 1993年 / 23卷 / 02期

关键词：

BXD RECOMBINANT INBRED STRAINS; ALCOHOL; QUANTITATIVE TRAIT LOCI (QTL); QUANTITATIVE GENETICS; MOLECULAR GENETICS;

D O I：

10.1007/BF01067425

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Recombinant inbred (RI) strains can make an important contribution toward the merger of molecular genetics and quantitative genetics in the quest for quantitative trait loci (QTL). We present preliminary analyses of alcohol-related processes from our ongoing research using the BXD RI series. Issues concerning reliability, genetic correlations, and RI QTL analysis are discussed. Several strategies for replication and extension of QTL candidate regions are considered: F1 crosses between RI strains, F2 crosses, heterogeneous stock, interspecific backcrosses, QTL selection, and the use of murine QTL in chromosomal regions syntenic to human chromosomes as candidate chromosomal regions for human QTL.

引用

页码：197 / 211

页数：15

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