PREFERENTIAL MIGRATION OF ACTIVATED CD4+ AND CD8+ T-CELLS IN RESPONSE TO MIP-1-ALPHA AND MIP-1-BETA

被引：746

作者：

TAUB, DD ^{[1
]}

CONLON, K ^{[1
]}

LLOYD, AR ^{[1
]}

OPPENHEIM, JJ ^{[1
]}

KELVIN, DJ ^{[1
]}

机构：

[1] NCI,FCRDC,BIOL RESPONSE MODIFIER PROGRAM,EXPTL IMMUNOL LAB,FREDERICK,MD 21702

来源：

SCIENCE | 1993年 / 260卷 / 5106期

关键词：

D O I：

10.1126/science.7682337

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recombinant human macrophage inflammatory protein-1alpha (rhMIP-1alpha) and rhMIP-1beta were potent chemoattractants of human T lymphocytes. These rhMIP-1 cytokines attracted only T cells activated by monoclonal antibody to CD3 and did not attract unstimulated lymphocytes. Phenotypic analysis revealed that CD4+ T cells were capable of migrating in response to rhMIP-1beta, whereas rhMIP-1alpha induced chemotaxis of predominantly CD8+ T lymphocytes. Activated naive and memory T cells also migrated in response to rhMIP-1 cytokines. Furthermore, these cytokines enhanced the ability of T cells to bind to an endothelial cell monolayer. These results suggest that rhMIP-1 cytokines preferentially recruit specific T cell subsets during the evolution of the immune response.

引用

页码：355 / 358

页数：4

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