LATENT INFECTION OF EPIDERMAL LANGERHANS CELLS IN HIV-POSITIVE INDIVIDUALS

被引：13

作者：

BRAATHEN, LR

RAMIREZ, G

KUNZE, ROF

MORK, C

STRAND, O

机构：

[1] SENTRALSYKEHUSET I AKERSHUS,DEPT INTERNAL MED,NORBYHAGEN,NORWAY

[2] BUNDESGESUNDHEITSAMT,ROBERT KOCH INST,DEPT VIROL,W-1000 BERLIN 33,GERMANY

来源：

RESEARCH IN VIROLOGY | 1991年 / 142卷 / 2-3期

关键词：

HIV; MONOCYTE; LANGERHANS CELL; SKIN; LATENT INFECTION;

D O I：

10.1016/0923-2516(91)90047-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Epidermal cell suspensions obtained from 3 symptom-free HIV-positive individuals were cultured and marked with monoclonal antibodies for the HIV proteins p15, p24 and gp120 in the alkaline phosphatase anti-alkaline phosphatase staining technique. For 2 individuals, cells were positive after 3 days in culture, and for the third, after 4 days. Supernatant from one of the cultures infected allogeneic peripheral blood mononuclear cells. We conclude that epidermal Langerhans cells from symptom-free HIV-positive individuals are latent-infected and are able to produce and release HIV.

引用

页码：119 / 121

页数：3

共 15 条

[1] RETROVIRAL INFECTION OF ACCESSORY CELLS AND THE IMMUNOLOGICAL PARADOX IN AIDS [J].