INHIBITION OF PEROXIDATIONS OF LIPIDS AND MEMBRANES BY ESTROGENS

被引：14

作者：

KOMURO, E ^{[1
]}

TAKAHASHI, M ^{[1
]}

MORITA, T ^{[1
]}

TSUCHIYA, J ^{[1
]}

ARAKAWA, Y ^{[1
]}

YAMAMOTO, Y ^{[1
]}

NIKI, E ^{[1
]}

SUGIOKA, K ^{[1
]}

NAKANO, M ^{[1
]}

机构：

[1] GUNMA UNIV, COLL MED CARE & TECHNOL, MAEBASHI, GUNMA 371, JAPAN

来源：

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY | 1990年 / 3卷 / 05期

关键词：

D O I：

10.1002/poc.610030507

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The antioxidant activity of 2‐hydroxyestradiol was measured quantitatively and compared with those of other estrogens in oxidations of methyl linoleate in homogeneous solution and in aqueous dispersions, oxidations of soybean phosphatidylcholine liposomal membranes and oxidative haemolysis of rabbit erythrocytes, all induced by free radicals generated from a radical initiator. Similar antioxidant activities of estrogens were observed, irrespective of the oxidation system. 2‐Hydroxyestradiol was found to be a potent radical scavenger and its antioxidant activity was close to that of α‐tocopherol, the strongest natural antioxidant. Other phenolic estrogens such as estrone, estriol and β‐estradiol showed a modest antioxidant activity and testosterone did not act as an antioxidant. Copyright © 1990 John Wiley & Sons Ltd.

引用

页码：309 / 315

页数：7

共 38 条

[1] AUTOXIDATION OF BIOLOGICAL MOLECULES .2. THE AUTOXIDATION OF A MODEL MEMBRANE - A COMPARISON OF THE AUTOXIDATION OF EGG LECITHIN PHOSPHATIDYLCHOLINE IN WATER AND IN CHLOROBENZENE [J].

BARCLAY, LRC ;

INGOLD, KU .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (21) :6478-6485

[2] IRREVERSIBLE BINDING OF ETHYNYL-ESTRADIOL METABOLITES TO PROTEIN AND NUCLEIC-ACIDS AS CATALYZED BY RAT-LIVER MICROSOMES AND MUSHROOM TYROSINASE [J].

BOLT, HM ;

KAPPUS, H .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1974, 5 (02) :179-184

[3] BIOLOGICAL ANTIOXIDANTS [J].

BURTON, GW ;

FOSTER, DO ;

PERLY, B ;

SLATER, TF ;

SMITH, ICP ;

INGOLD, KU .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1985, 311 (1152) :565-578

[4] AUTOXIDATION OF BIOLOGICAL MOLECULES .4. MAXIMIZING THE ANTIOXIDANT ACTIVITY OF PHENOLS [J].

BURTON, GW ;

DOBA, T ;

GABE, EJ ;

HUGHES, L ;

LEE, FL ;

PRASAD, L ;

INGOLD, KU .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (24) :7053-7065

[5] AUTOXIDATION OF BIOLOGICAL MOLECULES .1. THE ANTIOXIDANT ACTIVITY OF VITAMIN-E AND RELATED CHAIN-BREAKING PHENOLIC ANTIOXIDANTS INVITRO [J].

BURTON, GW ;

INGOLD, KU .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (21) :6472-6477

[6] AUTOXIDATION OF METHYL LINOLEATE, SEPARATION AND ANALYSIS OF ISOMERIC MIXTURES OF METHYL LINOLEATE HYDROPEROXIDES AND METHYL HYDROXYLINOLEATES [J].

CHAN, HWS ;

LEVETT, G .

LIPIDS, 1977, 12 (01) :99-104

[7]

CHOW CK, 1985, CELLULAR ANTIOXIDANT, V1

[8]

CHOW CK, 1985, CELLULAR ANTIOXIDANT, V2

[9] CHEMISTRY OF FREE-RADICAL AND SINGLET OXIDATION OF LIPIDS [J].

FRANKEL, EN .

PROGRESS IN LIPID RESEARCH, 1984, 23 (04) :197-221

[10]

Gelbke H P, 1977, Adv Steroid Biochem Pharmacol, V6, P81

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