MOLECULAR CONNECTIVITY STUDY OF HALOCARBON ANESTHETICS

被引：27

作者：

DIPAOLO, T

KIER, LB

HALL, LH

机构：

[1] MASSACHUSETTS COLL PHARM,BOSTON,MA 02115

[2] MED COLL VIRGINIA,DEPT PHARMACEUT CHEM,RICHMOND,VA 23298

[3] EASTERN NAZARENE COLL,DEPT CHEM,QUINCY,MA 02169

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 01期

关键词：

Anesthetic activity—various halogenated hydrocarbons; related to molecular connectivity indexes; Halogenated hydrocarbons; various—molecular connectivity indexes related to anesthetic activity; Molecular connectivity indexes—related to anesthetic activity of various halogenated hydrocarbons; Structure—activity relationships—molecular connectivity indexes related to anesthetic activity of various halogenated hydrocarbons; Topological indexes—molecular connectivity; related to anesthetic activity of various halogenated hydrocarbons;

D O I：

10.1002/jps.2600680114

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure‐activity relationships of 45 halogenated hydrocarbons using molecular connectivity were studied. A very good correlation was obtained between the anesthetic activity and the molecular connectivity term oχu in addition to the polar hydrogen factor, QH. The equation reported accounts for and quantifies the known structure‐activity observations on general anesthetics. The results are discussed briefly with reference to the mechanisms of action of general anesthetics. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：39 / 42

页数：4

共 21 条

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BELLAMY LJ, 1975, ADV INFRARED GROUP F, V2

[2] STRONG AMIDE-HALOTHANE HYDROGEN-BONDING OBSERVED BY NUCLEAR MAGNETIC-RESONANCE [J].