Cardiovascular Disease in Primary Sjogren's Syndrome

被引：13
作者：
Berardicurti, Onorina [1 ]
Ruscitti, Piero [1 ]
Cipriani, Paola [1 ]
Ciccia, Francesco [2 ]
Liakouli, Vasiliki [1 ]
Guggino, Giuliana [2 ]
Carubbi, Francesco [1 ]
Di Benedetto, Paola [1 ]
Triolo, Giovanni [2 ]
Giacomelli, Roberto [1 ]
机构：
[1] Univ Aquila, Div Rheumatol, Laquila, Italy
[2] Univ Palermo, Div Rheumatol, Palermo, Italy
来源：
REVIEWS ON RECENT CLINICAL TRIALS | 2018年 / 13卷 / 03期
关键词：
Atherosclerosis; cardiovascular disease; cardiovascular risk; comorbidity; endothelial damage; Sjogren syndrome;
D O I：
10.2174/1574887113666180315130336
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background: A close relationship between rheumatic diseases and cardiovascular disease (CVD) has been reported, accounting for the higher mortality and morbidity observed in these patients. In the last years, it has been clearly reported that patients affected by primary Sjogren's syndrome (pSS) experienced an increased risk of CVD. Objective: This review aimed at investigating CVD, traditional cardiovascular (CV) risk factors and possible targeted therapeutic strategies in pSS patients. Method: Available literature concerning CV risk factors in pSS patients has been selected and discussed. Conclusion: Disease-related characteristics and traditional CV risk factors contribute to observed atherosclerotic damage in pSS patients. The pro-inflammatory mediators together with hypertension and type 2 diabetes, which are more prevalent in pSS patients, determine the increased CV burden. Future studies are needed to fully elucidate the role of possible targeted therapies.
引用
收藏
页码：164 / 169
页数：6
相关论文
共 88 条
[71]   Increased levels of circulating microparticles in primary Sjogren's syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity [J].
Sellam, Jeremie ;
Proulle, Valerie ;
Juengel, Astrid ;
Ittah, Marc ;
Richard, Corinne Miceli ;
Gottenberg, Jacques-Eric ;
Toti, Florence ;
Benessiano, Joelle ;
Gay, Steffen ;
Freyssinet, Jean-Marie ;
Mariette, Xavier .
ARTHRITIS RESEARCH & THERAPY, 2009, 11 (05)
[72]   Targeting B Cells in Atherosclerosis Closing the Gap From Bench to Bedside [J].
Tsiantoulas, Dimitrios ;
Sage, Andrew P. ;
Mallat, Ziad ;
Binder, Christoph J. .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2015, 35 (02) :296-302
[73]   Efficacy and safety of abatacept for patients with Sjogren's syndrome associated with rheumatoid arthritis: Rheumatoid Arthritis with Orencia Trial toward Sjogren's syndrome Endocrinopathy (ROSE) trial an open-label, one-year, prospective study Interim analysis of 32 patients for 24 weeks [J].
Tsuboi, Hiroto ;
Matsumoto, Isao ;
Hagiwara, Shinya ;
Hirota, Tomoya ;
Takahashi, Hiroyuki ;
Ebe, Hiroshi ;
Yokosawa, Masahiro ;
Hagiya, Chihiro ;
Asashima, Hiromitsu ;
Takai, Chinatsu ;
Miki, Haruka ;
Umeda, Naoto ;
Kondo, Yuya ;
Ogishima, Hiroshi ;
Suzuki, Takeshi ;
Hirata, Shintaro ;
Saito, Kazuyoshi ;
Tanaka, Yoshiya ;
Horai, Yoshiro ;
Nakamura, Hideki ;
Kawakami, Atsushi ;
Sumida, Takayuki .
MODERN RHEUMATOLOGY, 2015, 25 (02) :187-193
[74]  
Turkcapar N, 2005, J RHEUMATOL, V32, P1063
[75]  
Ursini F, 2017, CLIN EXP RHEUMATOL, V35, P18
[76]   TNF-alpha and insulin-resistance: metabolic effects of in vivo therapeutic blockade [J].
Ursini, F. .
REUMATISMO, 2009, 61 (04) :254-259
[77]   Plantar fascia enthesopathy is highly prevalent in diabetic patients without peripheral neuropathy and correlates with retinopathy and impaired kidney function [J].
Ursini, Francesco ;
Arturi, Franco ;
Nicolosi, Kassandra ;
Ammendolia, Antonio ;
D'Angelo, Salvatore ;
Russo, Emilio ;
Naty, Saverio ;
Bruno, Caterina ;
De Sarro, Giovambattista ;
Olivieri, Ignazio ;
Grembiale, Rosa Daniela .
PLOS ONE, 2017, 12 (03)
[78]   Complement C3 Is the Strongest Predictor of Whole-Body Insulin Sensitivity in Psoriatic Arthritis [J].
Ursini, Francesco ;
D'Angelo, Salvatore ;
Russo, Emilio ;
Nicolosi, Kassandra ;
Gallucci, Antonio ;
Chiaravalloti, Agostino ;
Bruno, Caterina ;
Naty, Saverio ;
De Sarro, Giovambattista ;
Olivieri, Ignazio ;
Grembiale, Rosa Daniela .
PLOS ONE, 2016, 11 (09)
[79]   Retrospective analysis of type 2 diabetes prevalence in a systemic sclerosis cohort from southern Italy:Comment on "Reduced incidence of Type 1 diabetes and Type 2 diabetes in systemic sclerosis: A nationwide cohort study" by Tseng et al., Joint Bone Spine 2016;83:307-13 [J].
Ursini, Francesco ;
D'Angelo, Salvatore ;
Padula, Angela ;
Gilio, Michele ;
Russo, Emilio ;
Naty, Saverio ;
De Sarro, Giovambattista ;
Grembiale, Rosa Daniela ;
Olivieri, Ignazio .
JOINT BONE SPINE, 2016, 83 (05) :611-612
[80]   Prevalence of Undiagnosed Diabetes in Rheumatoid Arthritis: an OGTT Study [J].
Ursini, Francesco ;
Russo, Emilio ;
D'Angelo, Salvatore ;
Arturi, Franco ;
Hribal, Marta Letizia ;
D'Antona, Lucia ;
Bruno, Caterina ;
Tripepi, Giovanni ;
Naty, Saverio ;
De Sarro, Giovambattista ;
Olivieri, Ignazio ;
Grembiale, Rosa Daniela .
MEDICINE, 2016, 95 (07) :e2552
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