METABOLISM CORRELATES OF COCAINE-INDUCED STEREOTYPY IN RATS

被引：13

作者：

ESTEVEZ, VS ^{[1
]}

HO, BT ^{[1
]}

ENGLERT, LF ^{[1
]}

机构：

[1] UNIV TEXAS,CTR HLTH SCI,HOUSTON,TX 77030

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 10卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Cocaine; Metabolism; Stereotyped behavior;

D O I：

10.1016/0091-3057(79)90099-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

An increase in stereotyped behavior was observed in rats injected daily with cocaine (40 mg/kg, IP), as compared with the first day. This increase persisted 14 days after discontinuation of the drug treatment, and corresponded to increased levels of 3H-cocaine, norcocaine and benzoylecgonine in brain. Pretreatment of the animals with SKF-525A, an inhibitor of cocaine demethylation, produced a decrease in stereotypy rating and concomitantly a lower level of 3H-norcocaine in the brain. The role of this metabolite in the production of cocaine-induced stereotyped behavior is discussed. © 1979.

引用

页码：267 / 271

页数：5

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