TEMPORALLY CONTROLLED TRANSDERMAL SYSTEMS - BIPHASIC TRANSDERMAL DELIVERY OF NITROGLYCERIN

被引：4
|
作者：
DINH, SM
COMFORT, AR
SHEVCHUK, I
BERNER, B
机构：
[1] Basic Pharmaceutics Research, Ciba-Geigy Corporation, Ardsley, NY 10502
来源：
JOURNAL OF MEMBRANE SCIENCE | 1994年 / 89卷 / 03期
关键词：
CONTROLLED RELEASE; DRUG PERMEABILITY; SKIN; DIFFUSION; TRANSDERMAL DELIVERY SYSTEMS;
D O I：
10.1016/0376-7388(94)80106-1
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
A novel biphasic transdermal drug delivery system was developed to provide a technology of varying the temporal rate of the drug input to optimize the chronopharmacological response. The biphasic profile of a drug across skin was obtained by using a permeation enhancer to provide a high initial flux, and a subsequently lower flux by the rapid depletion of the enhancer from a finite volume reservoir. A pseudo-steady-state model was developed to guide the formulation and the design of this system. The performance of a nitroglycerin biphasic transdermal system was demonstrated in vitro, using aqueous ethanol as an enhancer.
引用
收藏
页码：245 / 255
页数：11
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