LIQUID-CHROMATOGRAPHIC SEPARATION OF RADIOPHARMACEUTICAL LIGAND ENANTIOMERS

被引:6
作者
GREEN, JM
JONES, R
HARRISON, RD
EDWARDS, DS
GLAJCH, JL
机构
[1] DuPont Merck Pharmaceutical Company, North Billerica, MA 01862
来源
JOURNAL OF CHROMATOGRAPHY | 1993年 / 635卷 / 02期
关键词
D O I
10.1016/0021-9673(93)80362-C
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A unique cyclodextrin-based chiral separation is presented for enantiomers which do not fit the commonly held selection criteria for chiral separations. The enantiomers of N,N'-1,2-ethylenediylbis(cysteine), diethyl ester are separated as the analogous rhenium(V)oxo complexes using a Cyclobond II column and a methanol-water mobile phase. The rigidity added to the molecule via the formation of the metal complex is sufficient to replace the normal requirement for an aromatic ring in the molecule for successful separation.
引用
收藏
页码:203 / 209
页数:7
相关论文
共 15 条
[1]   OPTICAL RESOLUTION BY LIQUID-CHROMATOGRAPHY ON IMMOBILIZED BOVINE SERUM-ALBUMIN [J].
ALLENMARK, S .
JOURNAL OF LIQUID CHROMATOGRAPHY, 1986, 9 (2-3) :425-442
[2]   CYCLODEXTRIN BONDED PHASES FOR THE LIQUID-CHROMATOGRAPHIC SEPARATION OF OPTICAL, GEOMETRICAL, AND STRUCTURAL ISOMERS [J].
ARMSTRONG, DW ;
DEMOND, W .
JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1984, 22 (09) :411-415
[3]   DIMERIZATION OF AN INTERMEDIATE DURING SODIUM IN LIQUID AMMONIA REDUCTION OF L-THIAZOLIDINE-4-CARBOXYLIC ACID [J].
BLONDEAU, P ;
BERSE, C ;
GRAVEL, D .
CANADIAN JOURNAL OF CHEMISTRY, 1967, 45 (01) :49-&
[4]  
CABRERA K, 1990, AM LAB, V22, P22
[5]   FACILE RESOLUTION OF N-TERT-BUTOXY-CARBONYL AMINO-ACIDS - THE IMPORTANCE OF ENANTIOMERIC PURITY IN PEPTIDE-SYNTHESIS [J].
CHANG, SC ;
WANG, LR ;
ARMSTRONG, DW .
JOURNAL OF LIQUID CHROMATOGRAPHY, 1992, 15 (09) :1411-1429
[6]   ENANTIOSELECTIVITY OF COMPLEX-FORMATION IN LIGAND-EXCHANGE CHROMATOGRAPHIC SYSTEMS WITH CHIRAL STATIONARY AND OR CHIRAL MOBILE PHASES [J].
DAVANKOV, VA ;
KURGANOV, AA ;
PONOMAREVA, TM .
JOURNAL OF CHROMATOGRAPHY, 1988, 452 :309-316
[7]  
EDWARDS D, UNPUB
[8]   ALPHA-CYCLODEXTRIN, BETA-CYCLODEXTRIN AND GAMMA-CYCLODEXTRIN AS MOBILE PHASE ADDITIVES IN THE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERIC COMPOUNDS .2. OPTIMIZATION OF THE SEPARATION METHOD BY USING ALPHA-CYCLODEXTRIN, BETA-CYCLODEXTRIN AND GAMMA-CYCLODEXTRINS IN MIXTURE [J].
GAZDAG, M ;
SZEPESI, G ;
HUSZAR, L .
JOURNAL OF CHROMATOGRAPHY, 1988, 436 (01) :31-38
[9]  
GREEN JM, 1990, 200TH AM CHEM SOC NA
[10]  
ICHIDA A, 1988, AM LAB, V20, P100