EFFECTS OF HARMANE ON GROWTH AND INVIVO METABOLISM OF AFLATOXIN-B1 IN MALE AND FEMALE RATS

被引：0

作者：

BILLAUD, C

机构：

[1] Laboratoire de Biochimie Industrielle et Agro-alimentaire, Conservatoire National des Arts et Métiers, Paris Cedex 03, 75141, 292, rue Saint-Martin

来源：

FOOD ADDITIVES AND CONTAMINANTS | 1991年 / 8卷 / 06期

关键词：

HARMANE; AFLATOXIN B1; METABOLISM; GROWTH; RAT;

D O I：

10.1080/02652039109374029

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The role of harmane, a beta-carboline formed during pyrolysis of tryptophan, on the metabolism of AFB1, growth and some parameters of the nutritional status was investigated in the rat. Male and female Wistar rats were fed a semi-synthetic diet containing AFB1 (2 ppm), harmane (250 ppm) or both compounds, for 33 days after weaning. Qualitative and quantitative differences in the urinary and faecal excretion of parental compound and metabolites were assessed by HPLC analysis. Harmane did not modify appreciably the growth and the other nutritional parameters studied. Similar excretion patterns of AFB1 metabolites were observed in males and females. Harmane caused a limited increase in the excretion of AFM1 in faces but not in urine, without altering the growth process in rats of either sex.

引用

页码：713 / 722

页数：10

共 32 条

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