RHABDOMYOSARCOMA OF THE HEAD AND NECK IN CHILDREN

被引：16

作者：

COENE, IMJH

SCHOUWENBURG, PF

VOUTE, PA

MARION, J

BURGERS, V

HILGERS, FJM

机构：

[1] NETHERLANDS CANC INST, DEPT HEAD & NECK SURG, 1066 CX AMSTERDAM, NETHERLANDS

[2] EMMA CHILDRENS HOSP, ACAD MED CTR, DEPT PAEDIAT ONCOL, DIV PAEDIAT, AMSTERDAM, NETHERLANDS

[3] NETHERLANDS CANC INST, DEPT RADIOTHERAPY, 1066 CX AMSTERDAM, NETHERLANDS

来源：

CLINICAL OTOLARYNGOLOGY | 1992年 / 17卷 / 04期

关键词：

RHABDOMYOSARCOMA; HEAD AND NECK; CHILDREN; TREATMENT RESULTS; CLASSIFICATION;

D O I：

10.1111/j.1365-2273.1992.tb00998.x

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Twenty-two children, 9 male and 13 female, with a non-orbital rhabdomyosarcoma of the head and neck, treated between 1970 and 1988, have been reviewed. Since 1972, treatment has consisted of combination chemotherapy, and where necessary radiotherapy and/or surgery. Complete clinical remission after initial chemotherapy was observed in 21 children. Six children were cured after primary treatment but 15 developed recurrent disease. Thirteen children had a parameningeal localized tumour, with eventual meningeal involvement in 5. Survival in this group was worse than in the non-meningeal group. Lymph node metastasis at first presentation (5 patients) had no influence on prognosis, whereas development of lymph node metastases during follow-up resulted in 100% mortality. All patients were retrospectively classified according to both the IRS-classification and TNM-descriptive system. No correlation with either system could be established. Fourteen of 15 children with recurrent disease were treated, 4 of whom were cured. Thus, 10 out of 22 (45%) children were long-term survivors.

引用

页码：291 / 296

页数：6